Microbial production of mature human leukocyte interferons
AssigneesHoffman-La Roche Inc., Genentech, Inc.
InventorsDavid V. Goeddel, Sidney Pestka
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Abstract
Disclosed herein are methods and means of microbially producing, via recombinant DNA technology, mature human leukocyte interferons, useful in the treatment of viral and neoplastic diseases.
Claims46
A polypeptide of about 165-166 amino acids comprising the amino acid sequence of a mature human leukocyte interferon microbially produced and unaccompanied by any corresponding presequence or portion thereof.
A composition comprising a polypeptide of about 165-166 amino acids comprising the amino acid sequence of a mature human leukocyte interferon unaccompanied by any corresponding presequence or portion thereof, wherein the composition is free of other human proteins.
Dependencies are inferred from the claim text.