Human extracellular matrix-1

An isolated polypeptide comprising an amino acid sequence selected from the group consisting of:

• (a) the amino acid sequence of the full-length polypeptide encoded by the cDNA in ATCC Deposit No. 97302;
• (b) the amino acid sequence of the full-length polypeptide, excluding the N-terminal methionine residue, encoded by the cDNA in ATCC Deposit No. 97302;
• and
• (c) the amino acid sequence of the mature polypeptide encoded by the cDNA in ATCC Deposit No. 97302.

An isolated first polypeptide at least 90% identical to a second polypeptide selected from the group consisting of:

• (a) amino acid residues −19 to 521 of SEQ ID NO:2;
• (b) amino acid residues −18 to 521 of SEQ ID NO:2;
• and
• (c) amino acid residues 1 to 521 of SEQ ID NO:2,
• wherein the first polypeptide stimulates wound healing.

An isolated first polypeptide at least 90% identical to a second polypeptide selected from the group consisting of:

• (a) the amino acid sequence of the full-length polypeptide encoded by the cDNA in ATCC Deposit No. 97302;
• (b) the amino acid sequence of the full-length polypeptide, excluding the N-terminal methionine residue, encoded by the cDNA in ATCC Deposit No. 97302;
• and
• (c) the amino acid sequence of the mature polypeptide encoded by the cDNA in ATCC Deposit No. 97302,
• wherein the first polypeptide stimulates wound healing.

An isolated polypeptide comprising an amino acid sequence selected from the group consisting of:

• (a) a fragment of amino acid residues 1 to 521 of SEQ ID NO:2, wherein the fragment stimulates osteogenesis;
• (b) a fragment of amino acid residues 1 to 521 of SEQ ID NO:2, wherein the fragment stimulates angiogenesis;
• (c) a fragment of the full-length polypeptide encoded by the cDNA in ATCC Deposit No. 97302, wherein the fragment stimulates osteogenesis;
• and
• (d) a fragment of the full-length polypeptide encoded by the cDNA in ATCC Deposit No. 97302, wherein the fragment stimulates angiogenesis.