Potassium channel subunit polypeptide and polynucleotide compositions and uses therefor
AssigneeElan Pharmaceuticals, Inc.
InventorsJohn R. Forsayeth, Byron Zhao, Raymond A. Chavez
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Abstract
The present invention provides novel potassium channel subunits (denoted Kv-SL1 and Kv-SL2, and collectively as Kv-SL) and polynucleotides which identify and encode them. The invention also provides expression vectors and host cells comprising nucleic acid sequence encoding Kv-SL. The invention also provides antibodies of Kv-SL and methods of diagnosing and treating diseases associated with expression of Kv-SL, and screening assays employing the protein, nucleotide, and antibody compositions.
Claims10
An isolated and substantially purified Kv-SL1 protein having an amino acid sequence at least 85% identical to SEQ ID NO:3,
- wherein said protein is a voltage gated potassium ion channel subunit capable of effecting or modulating potassium ion conductance when associated with additional Kv subunits to form a channel which selectively conducts potassium ions therethrough.
A polypeptide consisting of a sequence selected from the group consisting of
- (a) the sequence between amino acids 223 and 481 of SEQ ID NO:3, and
- (b) the sequence SEQ ID NO:5.
A polypeptide consisting of a sequence selected from the group consisting of:
- (a) the sequence between amino acids 373 and 401 of SEQ ID NO:3, and
- (b) the sequence between amino acids 149 and 177 of SEQ ID NO:5.
Dependencies are inferred from the claim text.