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AssigneeConjuChem, Inc.
InventorsAlan M. Ezrin, Dominique P. Bridon, Darren L. Holmes, Peter G. Milner
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Conjugates are prepared from antinociceptive agents, particularly opioids or opioid analogs, more particularly dynorphins, endorphins, deltorphins, enkephalins or analogs thereof, by combining said antinociceptive agent with a material providing a functionally reactive group capable of reacting with a blood component (preferably a blood cell or protein). Said conjugates permit extension of the therapeutic life of the antinociceptive agent. They may be administered to patients to alleviate pain, produce analgesic effects, or assist in cases of narcotics withdrawal, and may also be used as probes for receptor activity. The administration to the patient may be made either in vivo or ex vivo and may be performed by either introducing the derivative including the reactive functional group into the patient's vascular system or preparing such a conjugate externally (or in vitro) and introducing that conjugate to the patient's vascular system.
A method for treating pain in a patient suffering therefrom, comprising administering to the patient an effective amount of an antinociceptive agent derivative that covalently bonds in vivo to a blood protein, the antinociceptive agent derivative comprising a reactive entity coupled to an antinociceptive agent, the reactive entity reacting in vivo with a functionality on the blood protein to form the covalent bond, the antinociceptive agent derivative being administered for a time and under conditions effective to induce analgesia.
A method for treating pain in a patient suffering therefrom, comprising administering to the patient an effective amount of an opioid derivative that covalently bonds in vivo to a blood protein, the opioid derivative comprising a reactive entity coupled to an opioid, the reactive entity reacting in vivo with a functionality on the blood protein to form the covalent bond, the opioid derivative being administered for a time and under conditions effective to induce analgesia.
A method for treating pain in a patient suffering therefrom, comprising administering to the patient an effective amount of a composition comprising an antinociceptive agent derivative that covalently bonds in vivo to a blood protein and a physiological carrier, the antinociceptive agent derivative comprising a reactive entity coupled to an antinociceptive agent, the reactive entity reacting in vivo with a functionality on the blood protein to form the covalent bond, the antinociceptive agent derivative being administered for a time and under conditions effective to induce analgesia.
A method for treating pain in a patient suffering therefrom, comprising administering to the patient an effective amount of a composition comprising an opioid derivative that covalently bonds in vivo to a blood protein and a physiological carrier, the opioid derivative comprising a reactive entity coupled to an opioid, the reactive entity reacting in vivo with a functionality on the blood protein to form the covalent bond, the opioid derivative being administered for a time and under conditions effective to induce analgesia.
Dependencies are inferred from the claim text.