Amylin agonist peptides and uses therefor

An agonist analogue of amylin having the amino acid sequence of 1A1-X-Asn-Thr-5Ala-Thr-Y-Ala-Thr-10Gln-Arg-Leu-B1-Asn-15Phe-Leu-C1-D1-E1-20F1-G1-Asn-H1-Gly-25I1-J1-Leu-K1-L130Thr-M1-Val-Gly-Ser-35Asn-Thr-Tyr-Z, wherein

• A1 is Lys, Ala, Ser or hydrogen,
• B1 is Ala, Set or Thr;
• C1 is Val, Leu or Ile;
• D1 is His or Arg;
• E1 is Ser or Thr;
• F1 is Ser, Thr, Gln or Asn;
• G1 is Asn, Gln or His;
• H1 is Phe, Leu or Tyr;
• I1 is Ala or Pro;
• J1 is Ile, Val, Ala or Leu;
• K1 is Ser, Pro, Leu, Ile or Thr;
• L1 is Ser, Pro or Thr;
• M1 is Asn, Asp, or Gln;
• X and Y are independently selected amino acid residues having side chains which are chemically bonded to each other to form an intramolecular linkage;
• and
• Z is amino, alkylamino, dialkylamino, cycloalkylamino, arylamino, aralkylamino, alkyloxy, aryloxy or aralkyloxy, and provided that when
• (a) A1 is Lys, B1 is Ala, C1 is Val, D1 is His, E1 is Ser, F1 is Ser, G1 is Asn, H1 is Phe, I1 is Ala, J1 is Ile, K1 is Ser, L1 is Ser, and M1 is Asn;
• (b) A1 is Lys, B1 is Ala, C1 is Ile, D1 is Arg, E1 is Ser, F1 is Ser, G1 is Asn, H1 is Leu, I1 is Ala, J1 is Ile, K1 is Ser, L1 is Pro, and M1 is Asn;
• (c) A1 is Lys, B1 is Ala, C1 is Val, D1 is Arg, E1 is Thr, F1 is Ser, G1 is Asn, H1 is Leu, I1 is Ala, J1 is Ile, K1 is Ser, L1 is Pro, and M1 is Asn;
• (d) A1 is Lys, B1 is Ala, C1 is Val, D1 is Arg, E1 is Ser, F1 is Ser, G1 is Asn, H1 is Leu, I1 is Pro, J1 is Val, K1 is Pro, L1 is Pro, and M1 is Asn;
• (e) A1 is Lys, B1 is Ala, C1 is Val, D1 is His, E1 is Ser, F1 is Asn, G1 is Asn, H1 is Leu, I1 is Pro, J1 is Val, K1 is Ser, L1 is Pro, and M1 is Asn;
• or
• (f) A1 is Lys, B1 is Thr, C1 is Val, D1 is Arg, E1 is Ser, F1 is Ser, G1 is His, H1 is Leu, I1 is Ala, J1 is Ala, K1 is Len, L1 is Pro, and M1 is Asp;
• then one or more of any of A1 to M1 is a D-amino acid and Z is not amino.