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US 6,610,748 B1Granted
Preventives/remedies for skin aging
AssigneeFujisawa Pharmaceutical Co., Ltd.
InventorsTsuguo Yabuta, Mitsuru Yasumura, Kunio Nakahara, Yusuke Furukawa, Kazuhiko Nomura, Manabu Murakami
Life of this patent
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Abstract
A composition for prophylaxis and therapy of dermal aging which comprises a substance having human leukocyte elastase inhibitory activity as an active ingredient.
Claims5
A method for treatment of dermal aging comprising:
- selecting a subject in need of treatment of dermal aging and
- externally administering to said subject a composition comprising a trifluoromethylketone derivative of the following formula or a pharmaceutically acceptable salt thereof:
- wherein:
- R1 represents
- a lower alkyl group having 1 or 2 substituents selected from the group consisting of carboxy, esterified carboxy and di-lower alkylcarbamoyl;
- a phenyl(lower)alkyl group that may optionally have halogen, amino or nitro on the phenyl moiety thereof and carboxy or esterified carboxy on the alkyl moiety thereof;
- a halophenyl group;
- a morpholino group;
- or
- a morpholino (lower) alkyl group;
- R2 and R3 each independently represent a lower alkyl group;
- X is either — or —NH—;
- and
- in a form and in an amount suitable for treating dermal aging.
11 more elements
A method for inducing neogenesis of collagen fiber in skin, comprising:
- selecting a subject in need of the induction of the neogenesis of collagen fiber in skin, and
- administering to the skin of said subject an amount of a composition comprising a trifluoromethylketone derivative of the following formula or a pharmaceutically acceptable salt thereof:
- wherein:
- R1 represents
- a lower alkyl group having 1 or 2 substituents selected from the group consisting of carboxy, esterified carboxy and di-lower alkylcarbamoyl;
- a phenyl(lower)alkyl group that may optionally have halogen, amino or nitro on the phenyl moiety thereof and carboxy or esterified carboxy on the alkyl moiety thereof;
- a halophenyl group;
- a morpholino group;
- or
- a morpholino (lower) alkyl group;
- R2 and R3 each independently represent a lower alkyl group;
- X is either — or —NH—;
- and
- in a form and in an amount effective to induce neogenesis of collagen fiber in skin.
11 more elements
A method for inducing the growth of elastin fibrils in skin, comprising:
- selecting a subject in need of the induction of the growth of elastin fibers in skin, and
- externally administering to the skin of said subject a composition comprising a trifluoromethylketone derivative of the following formula or a pharmaceutically acceptable salt thereof:
- wherein:
- R1 represents
- a lower alkyl group having 1 or 2 substituents selected from the group consisting of carboxy, esterified carboxy and di-lower alkylcarbamoyl;
- a phenyl(lower)alkyl group that may optionally have halogen, amino or nitro on the phenyl moiety thereof and carboxy or esterified carboxy on the alkyl moiety thereof;
- a halophenyl group;
- a morpholino group;
- or
- a morpholino (lower) alkyl group;
- R2 and R3 each independently represent a lower alkyl group;
- X is either — or —NH—;
- and
- in a form and in an amount effective to induce the growth of elastin fibers.
11 more elements
A method for increasing epidermal thickness, comprising:
- selecting a subject in need of an increase in epidermal thickness, and
- externally administering to the skin of said subject a composition comprising a trifluoromethylketone derivative of the following formula or a pharmaceutically acceptable salt thereof:
- wherein:
- R1 represents
- a lower alkyl group having 1 or 2 substituents selected from the group consisting of carboxy, esterified carboxy and di-lower alkylcarbamoyl;
- a phenyl(lower)alkyl group that may optionally have halogen, amino or nitro on the phenyl moiety thereof and carboxy or esterified carboxy on the alkyl moiety thereof;
- a halophenyl group;
- a morpholino group;
- or
- a morpholino (lower) alkyl group;
- R2 and R3 each independently represent a lower alkyl group;
- X is either — or —NH—;
- and
- in a form and in an amount effective to increase the epidermal thickness.
11 more elements
A method for the treatment of wrinkles, comprising:
- selecting a subject in need of the reduction or elimination of wrinkles, and
- externally administering to the skin of said subject a composition comprising a trifluoromethylketone derivative of the following formula or a pharmaceutically acceptable salt thereof:
- wherein:
- R1 represents
- a lower alkyl group having 1 or 2 substituents selected from the group consisting of carboxy, esterified carboxy and di-lower alkylcarbamoyl;
- a phenyl(lower)alkyl group that may optionally have halogen, amino or nitro on the phenyl moiety thereof and carboxy or esterified carboxy on the alkyl moiety thereof;
- a halophenyl group;
- a morpholino group;
- or
- a morpholino (lower) alkyl group;
- R2 and R3 each independently represent a lower alkyl group;
- X is either — or —NH—;
- and
- in a form and in an amount effective to reduce or eliminate wrinkles.
11 more elements
Dependencies are inferred from the claim text.