Phenoxybenzylamine derivatives as SSRIs

A compound of general formula (I), pharmaceutically acceptable salts, or solvates or polymorphs thereof;

• wherein;
• R1 and R2, which may be the same or different, are H, C1-C6alkyl or (CH2)d(C3-C6cycloalkyl) wherein d=0, 1, 2 or 3;
• or R1 and R2 together with the nitrogen to which they are attached form an azetidine ring;
• Z or Y is —SR3 and other Z or Y is halogen or —R3;
• wherein R3 is independently C1-C4 alkyl optionally substituted with fluorine;
• except that R3 is not CF3;
• R4 and R5, which may be the same or different, are:
• A—X, wherein A=—CH═CH— or —(CH2)p— where p is 0, 1 or 2;
• X is hydrogen, F, Cl, Br, I, CONR6R7, SO2NR6R7, SO2NHC(═O)R6, OH, C1-4alkoxy, NR8SO2R9, NO2, NR6R11, CN, CO2R10, CHO, SR10, S(O)R9 or SO2R10;
• R6, R7, R8 and R10 which may be the same or different, are hydrogen or C1-6alkyl optionally substituted independently by one or more R12;
• R9 is C1-6 alkyl optionally substituted independently by one or more R12;
• R11 is hydrogen, C1-6 alkyl optionally substituted independently by one or more R12, C(O)R6, CO2R9, C(O)NHR6 or SO2NR6R7;
• R12 is F, OH, CO2H, C3-6cycloalkyl, NH2, CONH2, C1-6alkoxy, C1-6alkoxycarbonyl or a 5- or 6-membered heterocyclic ring containing 1, 2 or 3 heteroatoms selected from N, S and O optionally substituted independently by one or more R13;
• or R6 and R7, together with the nitrogen to which they are attached, form a 4-, 5- or 6-membered heterocyclic ring optionally substituted independently by one or more R13;
• or
• a 5- or 6-membered heterocyclic ring containing 1, 2 or 3 heteroatoms selected from N, S and O, optionally substituted independently by one or more R13;
• wherein R13 is hydroxy, C1-C4alkoxy, F, C1-C6alkyl, haloalkyl, haloalkoxy, —NH2, —NH(C1-C6alkyl) or —N(C1-C6alkyl)2.