Anhydro sugar derivatives of indolocarbazoles

A compound of Formula (I)

• or pharmaceutically acceptable salt or solvate thereof wherein,
• R is hydrogen, OH, OC1-7alkyl, NH2, N(C1-3alkyl)2 or C1-7alkyl, wherein said C 1-7alkyl is optionally substituted with one or more substituents selected from the group consisting of halogen, CN, OR9 and NR9R10;
• Q is O, S, CH2 or NR5a;
• one of R5 and R5a is Formula (A):
• and the other is hydrogen;
• R1, R2, R3 and R4 are each independently selected from the group consisting of hydrogen, C1-7alkyl, C3-7cycloalkyl, halogen, azido, NR9R10, NHC(O)NR9R10, NHC(O)OR9, C(O)OR9, SR9 and OR9, wherein said C1-7alkyl is optionally substituted with one or more substituents selected from the group consisting of halogen, CN, OR9, SR9 and NR9R10;
• or R1 and R2 together form ═N—OH, ═O or —NR9R10;
• or R3 and R4 together form ═N—OH, ═O or —NR9R10;
• W is selected from the group consisting of hydrogen, C1-7alkyl, C3-7cycloalkyl, halogen, azido, NR9R10, NHC(O)NR9R10, NHC(O)OR9, N—OH, O and OR9, wherein said C1-7alkyl is optionally substituted with one or more substituents selected from the group consisting of halogen, CN, OR9 and NR9R10;
• R7 and R8 are independently OH or H or together form ═O;
• R9 and R10 are independently selected from the group consisting of hydrogen, C1-7alkyl and C3-7cycloalkyl, wherein said C1-7alkyl is optionally substituted with one or more substituents selected from the group consisting of halogen, CN, OH, O—C1-7alkyl, NH2 and N(C1-3alkyl)2;
• or
• R9 and R10 together with the nitrogen atom to which they are attached form a non-aromatic 5-8 membered heterocycle containing one or two of the same or different heteroatoms selected from the group consisting of O, N and S;
• and
• X1, X1′, X2 and X2′ are independently selected from the group consisting of hydrogen, halogen, cyano, OR9, —CF3, alkylcarbonyl, C-1-7alkyl, nitro, NR9R10, SR9 and C(O)OR9;
• wherein said C1-7alkyl is optionally substituted with one or more substituents selected from the group consisting of halogen, CN, OR9, SR9 and NR9R10.