Compositions and agents for modulating cellular proliferation and angiogenesis
AssigneeNorth Shore-Long Island Jewish Research Institute
InventorsSivaram Pillarisetti, Itzhak D. Goldberg
Life of this patent
Estimating the term…
Abstract
The invention is directed to pharmaceutical compositions containing small organic molecules having the ability to mimic or agonize hepatocyte growth factor/scatter factor (HGF/SF) activity, useful for promoting, for example, vascularization of tissues or organs for promoting wound or tissue healing, or augmenting or restoring blood flow to ischemic tissues such as the heart following myocardial infarction.
Claims12
A pharmaceutical composition comprising an effective HGF/SF activity modulating amount of a compound with the general formula:
- wherein
- R1 is SO2Alkyl, wherein alkyl is a C1 to C4 a straight chain, branched or a cycloalkyl group;
- SO2-Aryl wherein aryl is halo, C1 to C4 alkyl or alkoxy substituted phenyl;
- COAlkyl, wherein alkyl is C1 to C6 straight chain alkyl, branched alkyl, or cycloalkyl;
- COAryl, wherein Aryl is phenyl substituted with halo, C1 to C4 alkyl or alkyloxy, trifluoromethyl, difluormethyl, nitro, hydroxy, amine, or another aryl or another heteroaryl;
- CONHAlkyl wherein alkyl is C1 to C6 straight chained alkyl, branched alkyl, or cycloalkyl;
- or CONHAryl, wherein aryl is a phenyl substituted with halo, C1 to C4 alkyl or C1 to C4 alkyloxy;
- and
- R3 is CHCH-heteroaryl;
- phenoxyphenyl;
- heteroaryl;
- or aryl substituted heteroaryl;
- and a pharmaceutically acceptable carrier, excipient, or diluent.
A compound with the general formula I:
- wherein:
- R1 is SO2Alkyl, wherein alkyl is a C1 to C4 straight chain, branched or a cycloalkyl group;
- SO2-Aryl, wherein aryl is halo, C1 to C4 alkyl or alkoxy substituted phenyl;
- COAlkyl, wherein alkyl is C1 to C6 straight chain alkyl, branched alkyl, or cycloalkyl;
- COAryl, wherein Aryl is phenyl substituted with halo, C1 to C4 alkyl or alkyloxy, trifluoromethyl, difluormethyl, nitro, hydroxy, amine, or another aryl or another heteroaryl;
- CONHAlkyl wherein alkyl is C1 to C6 straight chained alkyl, branched alkyl, or cycloalkyl;
- or CONHAryl, wherein aryl is a phenyl substituted with halo, C1 to C4 alkyl or C1 to C4 alkyloxy;
- and
- R3 is CHCH-heteroaryl;
- phenoxyphenyl;
- heteroaryl;
- or aryl substituted heteroaryl.
A method for prophylaxis or treatment of an ischemic condition in a mammal comprising administering to said mammal an effective amount of a pharmaceutical composition comprising a compound of Formula I:
- wherein:
- R1 is SO2Alkyl, wherein alkyl is a C1 to C4 straight chain, branched or a cycloalkyl group;
- SO2-Aryl, wherein aryl is halo, C1 to C4 alkyl or alkoxy substituted phenyl;
- COAlkyl, wherein Alkyl is C1 to C6 straight chain alkyl, branched alkyl, or cycloalkyl;
- COAryl, wherein Aryl is phenyl substituted with halo, C1 to C4 alkyl or alkyloxy, trifluoromethyl, difluormethyl, nitro, hydroxy, amine, or another aryl or another heteroaryl;
- CONHAlkyl wherein alkyl is C1 to C6 straight chained alkyl, branched alkyl, or cycloalkyl;
- or CONHAryl, wherein aryl is a phenyl substituted with halo, C1 to C4 alkyl or C1 to C4 alkyloxy;
- and
- R3 is CHCH-heteroaryl;
- phenoxyphenyl;
- heteroaryl;
- or aryl substituted heteroaryl.
Dependencies are inferred from the claim text.