3-Aminopyrazole inhibitors of cyclin dependent kinases

A compound of the formula:

• and pharmaceutically acceptable salts thereof wherein:
• R1 is R2, COR3, CONH2, CONR2R3, COOR3, or SO2R3;
• R2 is H, alkyl, cycloalkyl, heterocycloalkyl, cycloalkylalkyl, heterocycloalkylalkyl, aryl, heteroaryl, arylalkyl, heteroarylalkyl, or heteroarylium;
• R3 is alkyl, cycloalkyl, heterocycloalkyl, cycloalkylalkyl, heterocycloalkylalkyl, aryl, heteroaryl, arylalkyl, heteroarylalkyl;
• wherein i, j=0 or 1 but cannot both be 1, and Y is optionally substituted ethylene, alkene, alkyne, or any 2 adjacent carbon atoms of a cycloalkyl or cycloheteroalkyl ring of 3-7 atoms;
• R4 is R9;
• each R5, R6, R7, R8 is, independently, H, alkyl, cycloalkyl, heterocycloalkyl, cycloalkylalkyl, heterocycloalkylalkyl, aryl, heteroaryl, arylalkyl, heteroarylalkyl, halo, or
• hydroxy, alkoxy, amino, NR15R16, thio, or alkylthio with the proviso that only one such heteroatom group is bonded to any one carbon atom;
• wherein Z is NR12;
• each R10, R11 is, independently, H, alkyl, cycloalkyl, heterocycloalkyl, cycloalkylalkyl, heterocycloalkylalkyl, aryl, heteroaryl, arylalkyl, heteroarylalkyl, halo, hydroxy, alkoxy, alkylcarbonyloxy, carboxy, alkyloxycarbonyl, amino, NR13R14, carbamoyl, ureido, thio, or alkylthio;
• and
• each R12, R13, R14, R15, and R16 is, independently, H, alkyl, cycloalkyl, heterocycloalkyl, cycloalkylalkyl, heterocycloalkylalkyl, aryl, heteroaryl, arylalkyl, or heteroarylalkyl.