Dihydropyridine derivatives

A dihydropyridine compound represented by the formula (1) or a pharmaceutically acceptable salt thereof:

• wherein
• A represents a group of the formula (2), or 1-naphthyl, 2-naphthyl, thiophene-3-yl, thiophene-2-yl, furan-3-yl, furan-2-yl, pyridine-4-yl, pyridine-3-yl, pyridine-2-yl, indole-2-yl or indole-3-yl group:
• wherein
• R1, R2, R3, R4 and R5 may be the same or different from each other and each represent hydrogen atom, a halogen atom, hydroxyl group, carboxyl group, amino group, cyano group, a nitro group, a lower alkyl group, a lower alkoxyl group, a lower alkenyl group, a lower alkynyl group, a lower alkylamino group, a lower alkylthio group, a lower alkanoyl group, a lower alkoxycarbonyl group, a hydroxy-lower alkyl group, a hydroxy-lower alkoxyl group, a hydroxy-lower alkenyl group, a halogeno-lower alkyl group, a halogeno-lower alkoxyl group, a halogeno-lower alkenyl group, an aryl group, a heteroaryl group, an aryl-lower alkoxyl group or an aroyl group,
• B represents cyano group, nitro group, acetyl group, tetrazole group, triazole group or a group of the formula (3) or (4):
• wherein
• R6 to R8 each represent hydrogen atom, a linear, branched or cyclic, saturated or unsaturated hydrocarbon group having 1 to 6 carbon atoms, an alkyl group substituted with a cyclic alkyl group which may contain a hetero atom, a substituted or unsubstituted aryl group, a substituted or unsubstituted heteroaryl group, a hydroxy-lower alkyl group, a hydroxy-lower alkenyl group, a halogeno-lower alkyl group, a halogeno-lower alkenyl group, an aryl-lower alkyl group, an aryl-lower alkenyl group, a heteroaryl-lower alkyl group (excluding pyridine-3-ylpropyl group), a heteroaryl-lower alkenyl group, a cyano-lower alkyl group or a cyano-lower alkenyl group, or R7 and R8 may together form a ring which may contain a hetero atom,
• C represents hydrogen atom, a lower alkyl group, dimethoxymethyl group, cyano group, a hydroxy-lower alkyl group, a halogeno-lower alkyl group (C does not represent these groups listed above when E represents hydrogen atom, a lower alkyl group, dimethoxymethyl group, cyano group, a hydroxy lower alkyl group or a halogeno-lower alkyl group), a substituted or unsubstituted amino-lower alkyl group (the substituent represents hydrogen atom or a lower alkyl group), an azido-lower alkyl group, an aryl group, a heteroaryl group, an aryl-lower alkyl group, a heteroaryl-lower alkyl group or a lower alkyl group substituted with a cyclic alkyl group which may contain a hetero atom in the group,
• D represents hydrogen atom, a lower alkyl group, a hydroxy-lower alkyl group or an aryl-lower alkyl group,
• E represents hydrogen atom, a lower alkyl group, dimethoxymethyl group, cyano group, a hydroxy-lower alkyl group, a halogeno-lower alkyl group (E does not represent these groups listed above when C represents hydrogen atom, a lower alkyl group, dimethoxymethyl group, cyano group, a hydroxy lower alkyl group or a halogeno-lower alkyl group), a substituted or unsubstituted amino-lower alkyl group (the substituent represents hydrogen atom or a lower alkyl group, and if necessary, they may contain a hetero atom in the chain thereof), an azido-lower alkyl group, an aryl group, a heteroaryl group, an aryl-lower alkyl group, a heteroaryl-lower alkyl group or a lower alkyl group substituted with a cyclic alkyl group which may contain a hetero atom in the group,
• F represents an aryl group, a heteroaryl group or a cyclic alkyl group which may contain a hetero atom in the group, excluding piperidinyl group and piperazinyl group,
• G represents hydrogen atom or a lower alkyl group,
• X1 represents an interatomic bond, —CH2—, —CH2CH2—, —CH═CH— or —C≡C—, and
• Y represents a group represented by any of the following formulae (5) to (14):
• wherein
• R9 to R12, R and R0 may the same or different from each other, and they each represent hydrogen atom, a lower alkyl group, a hydroxy-lower alkyl group, a thio-lower alkyl group, an alkylthio-lower alkyl group, an aryl group, an aryl-lower alkyl group or a heteroaryl-lower alkyl group,
• B and C may together form a lactone ring or a lactam ring, two of R1 to R3 may be bonded together to form a ring, R9 and R10 be bonded together to form a ring, and R0 may be condensed with F to form a ring.