Process for the preparation of diaryl naphthyl methanes
AssigneeCouncil of Scientific and Industrial Research
InventorsNeeta Srivastava, Arvinder Grover
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Abstract
The invention relates to novel diaryl naphthyl methane compounds having general formula I as shown herein below, and said compounds useful in the treatment of esterogen related disease or syndrome, Pharmaceutical compositions comprising said novel methane derivatives, process for the preparation of the novel methane derivatives and methods for the treatment of esterogen related diseases or syndrome.
Claims23
A diaryl tetrahydro-naphthyl methane compound or a pharmaceutically acceptable acid addition salt thereof, wherein the diaryl tetrahydro-naphthyl compound is of formula I:
- wherein R1, R2, R3, R4, and R5 are each individually selected from the group consisting of H, OH, lower alkyl, lower alkoxy and substituted lower alkoxy group, wherein the lower alkyl and lower alkyl portion of the lower alkoxy group is a straight or branched chain radical containing 1-6 carbon atoms:
- wherein at least one of R2, R3, R4 and R5 is an alkoxy group substituted with at least one selected from the group consisting of hydrogen, hydroxy, epoxy, alkylamino, dialkylamino, cyclic alkyl amino and N(CH2)n, wherein n=2 to 8;
- and wherein the dotted lines on the naphthyl rings represent a 1,2,3,4-tetrahydronaphthyl ring or a 5,6,7,8-tetrahydronaphthyl ring.
A diaryl naphthyl methane compound or a pharmaceutically acceptable acid addition salt thereof, wherein the diaryl naphthyl compound is of formula I:
- wherein R1, R2, R3, R4, and R5 are each individually selected from the group consisting of H, OH, lower alkyl, lower alkoxy and substituted lower alkoxy group, wherein the lower alkyl and lower alkyl portion of the lower alkoxy group is a straight or branched chain radical containing 1-6 carbon atoms:
- wherein at least one of R2, R3, R4 and R5 is an alkoxy group substituted with at least one selected from the group consisting of hydroxy, amino, alkylamino, dialkylamino and N(CH2)n, wherein n=2 to 8;
- and
- wherein the dotted lines on the naphthyl rings represent a naphthyl ring.
(4-methoxyphenyl)-(4-(2-hydroxy-3-cyclopropylamino-propoxy)-phenyl)-naphth-1-yl-methane or a pharmaceutically acceptable acid addition salt thereof.
Dependencies are inferred from the claim text.