Method for treatment of glycolipid storage diseases
AssigneesG.D. Searle & Co., Oxford University
InventorsGary S. Jacob, Frances M. Platt, Terry D. Butters, Raymond A. Dwek
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Abstract
A novel method is disclosed for the treatment of a patient affected with Gaucher's disease or other such glycolipid storage diseases. The method comprises administering to said patient a therapeutically effective amount of a long-chain N-alkyl derivative of deoxynojirimycin to alleviate or inhibit the glycolipid storage disease. The long-chain alkyl group has from nine to about 20 carbon atoms and preferably is nonyl or decyl.
Claims12
The method of treating a patient affected with a glycolipid storage disease characterized by the synthesis of glucosylceramide by glucosyltransferase in the biosynthesis of glycosphingolipid comprising administering to said patient a long-chain N-alkyl derivative of deoxynojirimycin having from nine to about twenty carbon atoms in the alkyl chain in an amount effective for alleviating or inhibiting said glycolipid storage disease.
The method of treating a patient affected with Gaucher's disease comprising administering to said patient a long-chain N-alkyl derivative of deoxynojirimycin having from nine to about twenty carbon atoms in the alkyl chain in an amount effective for alleviating or inhibiting said Gaucher's disease.
Dependencies are inferred from the claim text.