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US 6,610,702 B2Granted
Ammonium salts of inositol hexaphosphate, and uses thereof
AssigneeGMP Oxycell, Inc.
InventorsJean-Marie Lehn, Yves Claude Nicolau, Stephane P. Vincent
Life of this patent
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Abstract
The present invention comprises compounds, compositions thereof, and methods capable of delivering inositol hexaphospahte (IHP) to the cytoplasm of mammalian cells. In certain embodiments, the present invention relates to compounds, compositions thereof, and methods that enhance the ability of mammalian red blood cells to deliver oxygen, by delivering IHP to the cytoplasm of the red blood cells.
Claims7
A composition represented by structure 1:
- wherein
- nC+ represents nona-cyclohexylammonium-tri-sodium, bis-dicyclohexylammonium-deca-sodium, octa-dicyclohexylammonium, hepta-1-aza-3-hydroxyl-bicyclo[2.2.2]cyclooctanium, dodeca-1-aza-3-hydroxyl-bicyclo[2.2.2]cyclooctanium, nona-piperidinium, penta-H3N-Phe-OMe, nona-H3N-Phe-OMe, hexa-1-indanylammonium, hepta-2-norbornylammonium, nona-decahydroquinolinium, hepta-H3N-Phe-OEt, hexa-H3N-Phe-OEt, octa-H3N-sec-Leu-Ot-Bu, dodeca-diisopropylammonium, octa-H3N-Pro-Ot-Bu, deca-H3N-Tyr-OEt, tetra-cyclohexyl-1,2-bis-ammonium, nona-cycloheptylammonium, undeca-cyclopentylammonium, or undeca-cyclohexylammonium, penta-(N,N′-dibenzyl)-ethylenediammonium, octa menthyl-1,8-diammonium, penta cyclohexyl-(1,3-bismethylammonium), penta (±)-(1,2-trans-diphenyl)-ethylenediammonium, nona N-cyclohexyl-piperidinium, bis (N1,N3-cyclohexyl)-dipropylenetriammonium, tris tri-(N-cyclohexyl-2-amino-ethyl)-ammonium, tetra N,N′-di-(3-(N-cyclohexyl-amino)-propyl)-piperazinium, tris tri-(N-cycloheptyl-2-amino-ethyl)-ammonium, tri N,N′-di-(3-(N-cyclooctyl-amino)-propyl)-piperazinium, or bis N,N′,N″,N′″-tetrahexyl-cyclam;
- and
- An− represents a conjugate base of inositol hexaphosphate, wherein n equals the number of cations comprised by nC+.
1 more element
Dependencies are inferred from the claim text.