Use of L-carnitine and its alkanoyl derivatives in the preparation of medicaments with anticancer activity
AssigneeSigma-Tau Industrie Farmaceutiche Riunite S.p.A.
InventorsClaudio Cavazza, Claudio Pisano, Loredana Vesci
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Abstract
Alkanoyl L-carnitines of the formula: where R is hydrogen or a C2-8 alkanoyl group and X− is an anion of a pharmaceutically acceptable salt, are used in conjunction with anticancer agents such as taxol or bleomycin to improve the therapeutic index and reduce side effects typical of anticancer chemotherapy.
Claims8
A method of mitigating the side effects of anti-tumor therapy comprising the coordinated use of a therapeutically effective amount of an anticancer agent to treat tumors sensitive to said anticancer agent, wherein the anticancer agent is selected from the group consisting of taxol, carboplatin, bleomycin and vincristine, and a detoxifying amount of acetyl L-carnitine, or one of its pharmacologically acceptable salts, to reduce the toxicity induced by the anticancer agent, while at the same time conserving its anticancer efficacy.
Dependencies are inferred from the claim text.