Cyclodextrin sulfonates, guest inclusion complexes methods of making the same and related materials
AssigneeEastman Chemical Company
InventorsCharles M. Buchanan, Steven N. Falling, Juanelle L. Lambert, Shannon E. Large, Jozsef Szejtli, Lajos Szente, Laszlo Jicsinszky
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Abstract
This invention relates to new cyclodextrin derivatives, processes for producing these cyclodextrin derivatives, and inclusion complexes comprised of the new cyclodextrin derivatives and guest molecules, as well as methods of making such materials and related materials and methods of using the same.
Claims14
A cyclodextrin ether comprising at least one hydroxybutyl sulfonate substituent.
A cyclodextrin ether comprising at least one hydroxybutyl sulfonate sulfinate substituent.
A cyclodextrin ether comprising at least one hydroxybutyl disulfonate substituent.
A cyclodextrin ether comprising at least one R substituent and at least one hydroxybutyl sulfonate substituent, wherein R is derived from an O-alkylating agent other than 3,4-epoxy-1-butene.
A cyclodextrin ether comprising at least one R substituent and at least one hydroxybutyl sulfonate sulfinate substituent, wherein R is derived from an O-alkylating agent other than 3,4-epoxy-1-butene.
A cyclodextrin ether comprising at least one R substituent and at least one hydroxybutyl disulfonate substituent, wherein R is derived from an O-alkylating agent other than 3,4-epoxy-1-butene.
A water-soluble or water dispersible cyclodextrin ether host molecule comprising at least one substituent selected from the group consisting of hydroxybutyl sulfonate, hydroxybutyl sulfonate sulfinate, and hydroxylbutyl disulfonate, wherein the cyclodextrin ether host molecule before being sulfonated, sulfonated and sulfinated, or disulfonated has a total DS of hydroxybutenyl from about 0.02 to about 9.0 and is capable of forming host-guest complexes.
A water-soluble or water dispersible cyclodextrin ether host molecule comprising at least one R substituent and at least one substituent selected from the group consisting of hydroxybutyl sulfonate, hydroxybutyl sulfonate sulfinate, and hydroxylbutyl disulfonate, wherein R is derived from an O-alkylating agent other than 3,4-epoxy-1-butene, and wherein the cyclodextrin host molecule before being sulfonated, sulfonated and sulfinated, or disulfonated has a total DS of hydroxybutenyl from about 0.02 to about 9.0 and is capable of forming host-guest complexes.
A process for making a cyclodextrin ether comprising at least one substituent selected from the group consisting of hydroxybutyl sulfonate, hydroxybutyl sulfonate sulfinate, and hydroxylbutyl disulfonate, said process comprising the step of contacting hydroxybutenyl cyclodextrin with a source of bisulfite and optionally with hydrogen peroxide or sodium hypochlorite.
A process for making a cyclodextrin ether comprising at least one R substituent and at least one substituent selected from the group consisting of hydroxybutyl sulfonate, hydroxybutyl sulfonate sulfinate, and hydroxylbutyl disulfonate, wherein R is derived from an O-alkylating agent other than 3,4-epoxy-1-butene, said process comprising the step of contacting hydroxybutenyl cyclodextrin comprising at least one R substituent with a source of bisulfite and optionally with hydrogen peroxide or sodium hypochlorite.
A process for making a sulfonated, sulfonated and sulfinated, or disulfonated cyclodextrin ether, wherein the cyclodextrin ether comprises at least one 2-hydroxybutenyl substituent, said process comprising the step of contacting a cyclodextrin ether comprising 2-hydroxybutenyl substituents with a source of bisulfite and optionally with hydrogen peroxide or sodium hypochlorite.
A process for making a sulfonated, sulfonated and sulfinated, or disulfonated cyclodextrin ether from a cyclodextrin ether, comprising at least one R substituent and at least one 2-hydroxybutenyl substituent, wherein R is derived from an O-alkylating agent other than 3,4-epoxy-1-butene, said process comprising the step of contacting said cyclodextrin ether comprising at least one R substituent and at least one 2-hydroxybutenyl substituent with a source of bisulfite and optionally with hydrogen peroxide or sodium hypochlorite.
An inclusion complex comprising a water-soluble or water dispersible cyclodextrin ether host molecule and an included material, wherein the cyclodextrin ether comprises at least one substituent selected from the group consisting of hydroxybutyl sulfonate, hydroxybutyl sulfonate sulfinate, and hydroxylbutyl disulfonate, and wherein the cyclodextrin ether host molecule before being sulfonated, sulfonated and sulfinated, or disulfonated has a total DS of hydroxybutenyl from about 0.02 to about 9.0.
An inclusion complex comprising a water-soluble or water dispersible cyclodextrin ether host molecule and an included material, wherein the cyclodextrin ether host molecule comprises at least one R substituent and at least one substituent selected from the group consisting of hydroxybutyl sulfonate, hydroxybutyl sulfonate sulfinate, and hydroxylbutyl disulfonate, wherein R is derived from an O-alkylating agent other than 3,4-epoxy-1-butene, and wherein the cyclodextrin ether host molecule before being sulfonated, sulfonated and sulfinated, or disulfonated has a total DS of hydroxybutenyl from about 0.02 to about 9.0.
Dependencies are inferred from the claim text.