Immunostimulatory polynucleotide/immunomodulatory molecule conjugates
AssigneeThe Regents of the University of California
InventorsDennis A. Carson, Eyal Raz, Mark Roman
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Abstract
Immunostimulatory polynucleotide-immunomodulatory molecule conjugate compositions are disclosed. These compositions include a polynucleotide that is linked to an immunomodulatory molecule, which molecule comprises an antigen and may further comprise immunomodulators such as cytokines and adjuvants. The polynucleotide portion of the conjugate includes at least one immunostimulatory oligonucleotide nucleotide sequence (ISS). Methods of modulating an immune response upon administration of the polynucleotide-immunomodulatory conjugate preparation to a vertebrate host are also disclosed.
Claims59
An immunomodulatory composition comprising an immunomodulatory molecule, wherein said immunomodulatory molecule comprises an antigen, wherein the antigen is conjugated to an immunostimulatory polynucleotide (ISS-PN), said ISS-PN comprising an immunostimulatory sequence (ISS) comprising the sequence 5′-cytosine, guanine-3′, wherein the ISS is at least six nucleotides in length, wherein said ISS-PN is from 6 to about 200 nucleotides in length, and wherein the antigen is selected from a tumor antigen, a viral antigen, and an allergen.
Dependencies are inferred from the claim text.