Progenitor cells and methods and uses related thereto
AssigneeES Cell International PTE Ltd.
InventorsKuanghui Lu, Kevin Pang, Lee Rubin
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Abstract
The present invention relates to a substantially pure population of viable pancreatic progenitor cells, and methods for isolating such cells. The present invention further concerns certain therapeutic uses for such progenitor cells, and their progeny.
Claims16
A method for obtaining differentiated pancreatic cell types comprising:
- obtaining a cell suspension from an animal tissue;
- treating the cell suspension with a growth factor preparation;
- allowing proliferation of progenitor cells, which progenitor cells are propogated as non-adherent cells;
- and
- contacting said proliferated progenitor cells with a differentiation medium and an adherent matrix,
- wherein said progenitor cells adhere to said matrix and give rise to at least one differentiated pancreatic cell type.
A method for obtaining differentiated pancreatic cell types comprising contacting a pancreatic progenitor cell with an adherent matrix and a differentiation medium comprising a cAMP elevating agent and a PYY polypeptide, wherein said progenitor cell gives rise to at least one differentiated pancreatic cell type.
Dependencies are inferred from the claim text.