Suture material for wounds based on methylidene malonate

A method for the suture of wounds comprising:

• a) preheating to a temperature above its softening temperature, a biocompatible, bioadhesive mixture comprising at least 50% by weight of a methylidene malonate-based composition containing:
• 40 to 100% by weight of at least one methylidene malonate of formula (I)
• in which:
• A and B independently represent a group (a) or (b):
• in which R1 and R2 independently represent a linear or branched alkyl group with 1 to 6 carbon atoms, n is an integer between 1 and 5, and at least one of A and B represents a (b) group;
• and/or one or more methylidene malonate oligomers with a molecular weight less than or equal to 6,000 and including recurrent units of formula (II):
• in which A and B are as defined above;
• and
• 0 to 60% by weight of at least one methylidene malonate polymer with a molecular weight greater than 6,000 and including recurrent units of formula (II);
• b) applying within a wound a sufficient quantity of the preheated mixture.

A material comprising at least 90% by weight of a methylidene malonate composition containing:

• 50 to 90% by weight of at least one methylidene malonate oligomer with a molecular weight less than or equal to 6,000 and including recurrent units of formula (II):
• in which:
• A and B independently represent a group (a) or (b):
• in which R1 and R2 independently represent a linear or branched alkyl group with 1 to 6 carbon atoms, n is an integer between 1 and 5, and at least one of A and B represents a (b) group;
• and
• 10 to 50% by weight of at least one methylidene malonate polymer with a molecular weight greater than 6,000,
• said material having a glass transition temperature that is less than or equal to 0° C.

A material which comprising at least 90% by weight of a methylidene malonate composition containing:

• 50 to 90% by weight of at least one methylidene malonate oligomer with a molecular weight less than or equal to 3,000 and including recurrent units of formula (II):
• in which:
• A and B independently represent a group (a) or (b):
• in which R1 and R2 independently represent a linear or branched alkyl group with 1 to 6 carbon atoms, n is an integer between 1 and 5, and at least one of A and B represents a (b) group;
• and
• 10 to 50% by weight of at least one methylidene malonate polymer with a molecular weight greater than 6,000,
• said material having a glass transition temperature that is less than or equal to 0° C.

A material for the suture of wounds, comprising a biocompatible, bio-adhesive mixture comprising at least 50% by weight of a methylidene malonate-based composition containing:

• 40 to 100% by weight of at least one methylidene malonate of formula (I)
• in which:
• A and B independently represent a group (a) or (b):
• in which R1 and R2 independently represent a linear or branched alkyl group with 1 to 6 carbon atoms, n is an integer between 1 and 5, and at least one of A and B represents a (b) group;
• and/or at least one methylidene malonate oligomer with a molecular weight less than or equal to 6,000 and including recurrent units of formula (II):
• in which A and B are as defined above;
• 0 to 60% by weight of at least one methylidene malonate polymer with a molecular weight greater than 6,000 and including recurrent units of formula (II).