Use of PDT to inhibit intimal hyperplasia
AssigneesQLT Inc., The University of British Columbia
InventorsBeth Anne Allison, Philippe Maria Clotaire Margaron, York N. Hsiang
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Abstract
Long-term dialysis requires provision of safe and reliable vascular access, often in the form of an arteriovenous (AV) fistula. The primary cause of AV fistula loss or failure is stenosis caused by intimal hyperplasia (IH) in the graft at the venous anastomosis or the distal vein. Disclosed are methods of using photodynamic therapy (PDT) to inhibit IH in blood vessels which may also be used to inhibit IH and SMC growth at the anastomosis of an AV fistula in vivo.
Claims22
A method to prevent, treat, inhibit, or reduce intimal hyperplasia in a vein graft, artery graft or vascular graft in a subject, which method comprises
- contacting said graft in vivo with a photosensitizer at a concentration and for a time effective to photosensitive said graft tissue, and
- irradiating said photosensitized graft with radiation at a wavelength absorbed by the photosensitizer for a time and at an intensity to prevent, treat, inhibit, or reduce intimal hyperplasia in said graft,
- wherein the concentration, of the photosensitizer, the intensity of the radiation, and the total energy provided are adjusted to provide said graft with low-dose photodynamic therapy, and said graft optionally comprises a prosthetic conduit.
A method to prevent, treat, inhibit, or reduce intimal hyperplasia in an arteriovenous (AV) fistula in a subject, which method comprises
- contacting said AV fistula with a photosensitizer at a concentration and for a time effective to photosensitive said AV fistula tissue, and
- irradiating said photosensitized AV fistula with radiation at a wavelength absorbed by the photosensitizer for a time and at an intensity to prevent, treat, inhibit, or reduce intimal hyperplasia in said AV fistula,
- wherein the concentration of the photosensitizer, the intensity of the radiation, and the total energy provided are adjusted to provide said AV fistula with low-dose photodynamic therapy and
- wherein said prevention, treatment, inhibition, or reduction in intimal hyperplasia occurs at the anastomosis of the AV fistula.
Dependencies are inferred from the claim text.