Process for preparing vinylaromatic compounds
AssigneesPfizer Inc., Dsm N.V.
InventorJoseph Miller
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Abstract
The present invention provides a process for preparing a vinylaromatic compound comprising reacting an arylmetal reagent selected from arylmagnesium reagents and aryllithium reagents with a vinylphosphate in the presence of a palladium catalyst. The present invention also provides a process for preparing a vinylphosphate comprising reacting an enolizable ketone with a sterically hindered Grignard reagent and a halophosphate diester.
Claims21
A process for the preparation of a vinylaromatic compound comprising contacting a vinylphosphate with an arylmetal reagent selected from arylmagnesium reagents and aryllithium reagents in the presence of a palladium catalyst, under conditions sufficient for coupling to occur between the vinyl portion of said vinylphosphate and an aryl portion of said arylmetal reagent.
A process for the preparation of a vinylphosphate comprising reacting an enolizable ketone with a sterically hindered Grignard reagent and a halophosphate diester.
A process for the preparation of a 1-(4-alkoxyphenyl)-6-methoxy-3,4-dihydronaphthalene compound comprising the steps:
- (a) reacting 6-methoxy-1-tetralone with a mesityl Grignard reagent and a halophosphate diester to produce a 6-methoxy-3,4-dihydronaphth-1-yl phosphate compound;
- and
- (b) reacting the 6-methoxy-3,4-dihydronaphth-1-yl phosphate compound with a 4-alkoxyphenylnagnesium halide in the presence of a palladium catalyst comprising a phosphine ligand.
Dependencies are inferred from the claim text.