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US 6,608,208 B1Granted
Process for the preparation of 1,2-benzisothiazolin-3-ones
AssigneeZeneca Limited
InventorMark Robert James
Life of this patent
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Abstract
A process for making a 2-alkylbenzisothiazolinone which comprises reacting a bisamide of formula in water or an organic liquid containing water with a bisulphite or bisulphite release agent to form a Bunte salt and converting the Bunte salt under alkaline conditions to 2-alkyl-BIT. R is alkyl. Preferred substituents R are butyl, hexyl, 2-ethylbutyl and 2-ethylhexyl.
Claims5
A process for making BIT of formula 1
- which comprises reacting a bisamide of formula 5
- wherein,
- R is cycloalkyl containing from 3 to 8 carbons atoms or C1-20-alkyl optionally substituted by phenyl;
- X is halogen, nitro, alkoxy or nitrile;
- n is 0 to 4;
- and
- q is 0, 1, or 2
- in water or an organic liquid containing water with metabisulphite.
5 more elements
Dependencies are inferred from the claim text.