Process for producing substituted alkylamine derivative
AssigneeIhara Chemical Industry Co., Ltd.
InventorChikara Hijikata
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Abstract
The present invention lies in a process for producing a substituted alkylamine derivative represented by formula (3): (wherein X is halogen, alkyl, alkoxy, cyano or nitro; n is an integer of 1 to 4; and R1 and R2 are each independently hydrogen or phenyl substituted or unsubstituted alkyl and may together form a 5- or 6-membered ring) or an acid addition salt thereof, which process comprises adding a salt of a 2-aminothiophenol derivative represented by formula (1): into an acid to allow the system to have a pH of 6 or less and convert the salt into a free 2-aminothiophenol of formula (1) and then reacting the 2-aminothiophenol derivative with an amino acid-N-carboxyanhydride represented by formula (2):
Claims12
A process for producing a substituted alkylamine derivative represented by the following formula (3):
- wherein X is a halogen atom, an alkyl group, an alkoxy group, a cyano group or a nitro group;
- n is an integer of 1 to 4;
- and R1 and R2 are each independently a hydrogen atom or a phenyl group-substituted or unsubstituted alkyl group and may together form a 5- or 6-membered ring, which process comprises adding a salt of a 2-aminothiophenol derivative represented by the following formula (1):
- wherein X and n have the same definitions as given above, into an acid while controlling the pH of the system to 6 or less thereby converting the salt into a free 2-aminothiophenol derivative of the formula (1) and then reacting the 2-aminothiophenol derivative with an amino acid-N-carboxyanhydride represented by the following formula (2):
- wherein R1 and R2 each have the same definitions as given above.
A process for producing a substituted alkylamine derivative represented by the following formula (3):
- wherein X is a halogen atom, an alkyl group, an alkoxy group, a cyano group or a nitro group;
- n is an integer of 1 to 4;
- and R1 and R2 are each independently a hydrogen atom or a phenyl group-substituted or unsubstituted alkyl group and may together form a 5- or 6-membered ring, which process comprises adding a salt of a 2-aminothiophenol derivative represented by the following formula (1):
- wherein X and n have the same definitions as given above, into an acid while controlling the pH of the system to 6 or less thereby converting the salt into a free 2-aminothiophenol derivative of the formula (1) and then reacting, in water or a water-organic solvent mixture, the 2-aminothiophenol derivative with an amino acid-N-carboxyanhydride represented by the following formula (2):
- wherein R1 and R2 each have the same definitions as given above.
Dependencies are inferred from the claim text.