Synthesis of chlorinated pyrimidines
AssigneeSyngenta Limited
InventorsTimothy John Doyle, Alan Henry Benke, Peter Karl Wehrenberg, Louie Akos Nady
Life of this patent
Estimating the term…
Abstract
The invention provides a process for synthesizing chlorinated pyrimidines. The process includes reacting imidoyl chloride compounds with phosgene (COCl2). The imidoyl chloride compounds can be supplied as starting materials or can be produced by reacting organic amides with phosgene or reacting organic nitrites with hydrogen chloride. The chlorinated pyrimidines, such as 4,6-dichloropyrimidine, can be used to synthesize other compounds useful in a variety of compositions, such as fungicides, pesticides, and pharmaceuticals.
Claims26
A method of synthesizing 4,6-dichioropyrimidine, 5-substituted-4,6-dichloropyrimidines, 4-chloro-6-hydroxypyrimidine, or 5-substituted-4-chloro-6-hydroxypyrimidines, said method comprising reacting a first imidoyl chloride compound which is formamidoyl chloride and a second imidoyl chloride compound with phosgene, wherein the second imidoyl chloride compound has two alpha hydrogens and said imidoyl compounds are represented by the formulas:
- in which R1 is selected from hydrogen and a C1-C12 hydrocarbyl group.
Dependencies are inferred from the claim text.