C1 bacteriophage lytic system
AssigneeThe Rockefeller University
InventorsDaniel C. Nelson, Vincent A. Fischetti
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Abstract
The invention relates to the identification of C1 bacteriophage genes that express protein involved in the lysis of bacterial cells during the phage life cycle, lysin and holin. The invention further relates to methods for lysing certain bacteria using lysin, which are useful for example in the treatment of an oral cavity bacterial infection.
Claims12
An isolated nucleic acid encoding a C1 bacteriophage holin polypeptide, wherein the polypeptide comprises an amino acid sequence which is at least about 70% identical to the amino acid sequence as set forth in SEQ ID NO:4 and the polypeptide is able to penetrate the inner membrane of streptococcal bacteria.
Dependencies are inferred from the claim text.