Loading patent…
AssigneeThe Kitasato Institute
InventorsSatoshi Omura, Hiroshi Tomoda, Rokuro Masuma
Estimating the term…
A microorganism which belongs to the genus Gliocladium and has the ability to produce stereoisomers KF-1040T4A and KF-1040T4B which are compounds represented by the following formula [I], and stereoisomers KF-1040T5A and KF-1040T5B which are compounds represented by the following formula [II], is cultivated in a culture medium to accumulate KF-1040T4A and/or KF-1040T4B and/or KF-1040T5A and/or KF-1040T5B in the culture medium, and the substance KF-1040T4A and/or KF-1040T4B and/or KF-1040T5A and/or KF-1040T5B are harvested from the culture medium. The obtained substances are useful for the prevention and treatment of the diseases relating to arteriosclerosis, obesity, thrombosis, inflammations and immunofunctional disorders.
A substance selected from the group consisting of KF-1040T4A, KF-1040T4B, KF-1040T5A and KF-1040T5B, wherein KF-1040T4A and KF-1040T4B are stereoisomers of the compound represented by the following formula [I],
A process for producing substances KF-1040T4A, KF-1040T4B, KF-1040T5A and KF-1040T5B, comprising the steps of:
A microorganism which is Gliocladium KF-1040 (FERM BP-6251) and which produces a substance selected from the group consisting of KF-1040T4A, KF-1040T4B, KF-1040T5A and KF-1040T5B.
Dependencies are inferred from the claim text.