Fibroblast growth factor receptor activating gene I and related compositions and methods
AssigneeThe United States of America as represented by the Department of Health and Human Services
InventorsMatthew V. Lorenzi, Toru Miki
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Abstract
A novel gene designated as FRAG1 and its encoded protein is disclosed. A fusion protein called FGFR2-ROS, which is formed by chromosomal rearrangement of rat FRAG1 with FGFR2, is also disclosed. Methods of producing FRAG1 protein, related fusion proteins, and antibodies against FRAG1 are disclosed, as are related pharmaceuticals and methods of using such nucleic acids, polypeptides, and antibodies are also disclosed.
Claims75
An isolated FRAG-1 specific antibody which recognizes a FRAG-1 polypeptide comprising 7 or more amino acids of SEQ ID NO:
- 6 or SEQ ID NO:
- 12, wherein the polypeptide forms a stable protein dimer of a growth factor receptor when expressed as an in-frame fusion with the growth factor receptor.
The FRAG-1 specific antibody of claimy 2, wherein the antibody is a monoclonal antibody.
An isolated FRAG-1 specific antibody which recognizes a FRAG-1 polypeptide, wherein the polypeptide comprises at least 70% amino acid sequence homology to SEQ ID NO:
- 6 or SEQ ID NO:
- 12, and wherein the polypeptide forms a stable protein dimer of a growth factor receptor when expressed as an in-frame fusion with the growth factor receptor.
An isolated FRAG-1 specific antibody which recognizes a FRAG-1 polypeptide, wherein the polypeptide is encoded by a nucleic acid sequence comprising at least 70% nucleotide sequence identity to a protein-coding region of SEQ ID NO:
- 5 or 11, and wherein the polypeptide forms a stable protein dimer of a growth factor receptor when expressed as an in-frame fusion with the growth factor receptor.
The FRAG-1 specific antibody of ciaim 52, wherein the antibody is a monoclonal antibody.
Dependencies are inferred from the claim text.