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US 6,608,177 B1Granted
Rantes mutants and therapeutic applications thereof
AssigneeFondazione Centro San Raffaele Del Monte Tabor
InventorsPaolo Lusso, Simona Polo
Life of this patent
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Abstract
RANTES mutants characterized by the substitution or addition of amino acids at the N-terminal or RANTES wild-type sequence and in the N loop and/or 40′ loop regions of RNATES wild-type sequence, and their use as anti-HIV, anti-allergic or anti-inflammatory agents.
Claims2
A mutant of human RANTES, which has, as compared to human wild-type RANTES, a double mutation of Ser1 replaced with Cys and Ser5 replaced with Cys.
Dependencies are inferred from the claim text.