Methods and compositions to treat conditions associated with neovascularization
AssigneeWackvom Limited
InventorsKin-Ping Wong, Ming-Chung Wong
Life of this patent
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Abstract
This invention also provides a method to inhibit neovascularization in tissue by delivering to the cell or tissue an effective amount of gossypol, or a pharmaceutically acceptable salt, derivative or prodrug thereof. Also provided herein is a method for treating a disease associated with hyproliferation of endothelial cells and/or neovascularization by administering to a subject an effective amount of gossypol, or a pharmaceutically acceptable salt, derivative or prodrug thereof. Kits to treat patients are provided as well.
Claims41
A method for inhibiting the growth of endothelial cells, comprising delivering to the cells a growth inhibitory amount of gossypol, or a pharmaceutically acceptable derivative, salt or prodrug thereof.
A method of inhibiting vascularization in a tissue, comprising delivering to the tissue an anti-vascularization amount of gossypol, or a pharmaceutically acceptable derivative, salt or prodrug thereof.
A method of inhibiting vascularization in a major organ, comprising delivering to the tissue an anti-vascularization amount of (−) gossypol, or a pharmaceutically acceptable derivative, salt or prodrug thereof.
A method of inhibiting vascularization in kidney cells or tissue, comprising delivering to the tissue an anti-vascularization amount of (+) gossypol, or a pharmaceutically acceptable derivative, salt or prodrug thereof.
A method of treating a disorder associated with pathological neovascularization in a host, comprising administering to a subject a therapeutically effective amount of growth inhibitory amount of gossypol, or a pharmaceutically acceptable derivative, salt or prodrug thereof.
A method of treating a disorder associated with pathological neovascularization in a major organ in a subject, comprising administering to the subject a therapeutically effective amount of (−) gossypol, or a pharmaceutically acceptable derivative, salt or prodrug thereof.
A method of treating a disorder associated with pathological neovascularization in the kidney of a subject, comprising administering to the subject a therapeutically effective amount of (+) gossypol, or a pharmaceutically acceptable derivative, salt or prodrug thereof.
A method for improving the general health and well being of a subject comprising administering to the subject an effective amount of gossypol.
A method for screening for a therapeutic agent for inhibiting neovascularization or endothelial cell growth comprising the steps of:
- a. contacting the agent with a suitable cell or tissue sample;
- b. contacting a separate sample of the suitable cell or tissue sample with a therapeutically effective amount of gossypol or a pharmaceutically acceptable derivative, salt or prodrug thereof;
- and
- c. comparing the growth of the sample of step (a) with the growth of the sample of step (b), and wherein any agent of step (a) that inhibits the growth to the same or similar extent as the sample of step (b) is a therapeutic agent for inhibiting neovascularization or the growth of endothelial cells.
A kit for treating a disorder associated with pathological neovascularization in a subject, comprising a therapeutically effective amount of gossypol, or a pharmaceutically acceptable derivative, salt or prodrug thereof and instructions for use.
Dependencies are inferred from the claim text.