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AssigneeRutgers, The State University of New Jersey
InventorsAmy B. Howell, Nicholi Vorsa
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The present invention is directed to isolation and identification of plant proanthocyanidin extracts and particular proanthocyanidin compounds for prevention and treatment of urinary tract infections caused by P-type Escherichia coli. These extracts can be obtained from any proanthocyanidin-containing plants, including plants of the families Ericaceae, Rosaceae, Pinaceae, Vitaceae and the like. Preferably the extracts are from cranberry plants (especially, Vaccinium macrocarpon) and other plants, particularly fruit and berry plants from the Vaccinium spp. The extracts and compounds are also provided as pharmaceutical compositions, food additives and food compositions, especially beverages, ground meat preparations and cranberry-containing food products. The invention also relates to methods of reducing pathogenicity of P-type E. coli in the digestive tracts of cattle and reducing P-type E. coli contamination in ground meat as well as methods of detecting P-type bacteria.
A proanthocyanidin composition comprising proanthocyanidin compounds having an average of from at least four to about seven epicatechin flavanoid units, wherein each proanthocyanidin compound has at least two of said units are linked together by an A-type interflavanoid linkage by bonds between C4 and C8 and between C2 and the oxygen of C7 of the units, and the remainder of the units are linked to each other by a B-type interflavanoid bond between C4 and C8 or between C4 and C6 of the units.
Dependencies are inferred from the claim text.