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US 6,608,099 B1Granted
Indole sPLA2 inhibitors
AssigneeEli Lilly and Company
InventorsEdward David Mihelich, Michael LeRoy Phillips, Alan M Warshawsky
Life of this patent
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Abstract
A class of novel acylsulfonamide substituted indole compounds is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of inflammatory diseases.
Claims6
An indole compound represented by the formula (I), or a pharmaceutically acceptable salt, or solvate derivative thereof;
- wherein;
- R1 is the group —(L1)—R11, where, —(L1)— is —(CH2)— and R11 is C7-C20 alkyl, C7-C20 haloalkyl, C7-C20 alkenyl, C7-C20 alkynyl, or a carbocyclic radical;
- R2 is —CH3 or C2H5;
- R3 is —C(O)—C(O)—NH2;
- R4 is the group —(La)-(acylsulfonamide group) where —(La)— is —O—CH2— and the acylsulfonamide group is —C(O)—CH—S(O)(O)—R81 and R81 is —CF3, CH3 or C2H5;
- R5 is hydrogen;
- and
- R6 and R7 are hydrogen, or a carbocyclic radical.
5 more elements
A indole compound represented by the formula.
An indole compound selected from the group consisting of:
- 1-benzyl-2-ethyl-4-methanesulfonamidoylmethyloxy-indole-3-glyoxylamide;
- and
- 1-benzyl-2-ethyl-4-trifluoromethanesulfonamidoylmethyloxy-indole-3-glyoxylamide.
Dependencies are inferred from the claim text.