Compounds and methods for use thereof in the treatment of cancer or viral infections
AssigneeUniversity of Arizona Foundation
InventorsJames Berger Camden, James C. Quada, Jr., Joseph K. Agyin
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Abstract
Benzimidazole derivatives and salts and prodrugs thereof are disclosed, together with methods for the treatment of cancers or viral infections in warm-blooded animals by administration of these compounds. Such compounds may be used in combination with a chemotherapeutic agent and/or a potentiator.
Claims36
A method for treating cancer susceptible to treatment in a warm-blooded animal comprising administering to the warm-blooded animal a therapeutically effective amount of a compound of the following formula:
- wherein,
- R1 is —CONHR3;
- R3 is alkyl, haloalkyl, alkenyl, haloalkenyl, cycloalkyl, cycloalkalkyl, heterocycloalkyl, heterocycloalkalkyl, substituted or unsubstituted benzyl, hydroxyalkyl, alkoxyalkyl, poly(alkoxy)alkyl, hydroxyalkoxyalkyl, hydroxypoly(alkoxy)alkyl, haloalkoxyalkyl, halopoly(alkoxy)alkyl, or aminoalkyl;
- and
- each of X and Y is independently hydrogen, alkyl, alkenyl, cycloalkyl, haloalkyl, haloalkenyl, halogen, nitro, or amino;
- or a pharmaceutically acceptable salt thereof
- or ester thereof wherein the ester is a dimethylglycine, aminoalkylbenzyl, aminoalkyl or carboxyalkyl ester.
A method for treating cancer susceptible to treatment in a warm-blooded animal comprising administering to the warm-blooded animal a therapeutically effective amount of a compound of the following formula:
- wherein,
- R1 is —COOR3;
- R3 is haloalkyl, haloalkenyl, cycloalkyl, cycloalkalkyl, heterocycloalkyl, heterocycloalkyl, substituted or unsubstituted benzyl, hydroxyalkyl, alkoxyalkyl, poly(alkoxy)alkyl, hydroxyalkoxyalkyl, hydroxypoly(alkoxy)alkyl, haloalkoxyalkyl, halopoly(alkoxy)alkyl, or aminoalkyl;
- and
- each of X and Y is independently hydrogen, alkyl, alkenyl, cycloalkyl, haloalkyl, haloalkenyl, halogen, nitro, or amino;
- or a pharmaceutically acceptable salt thereof
- or ester thereof wherein the ester is a dimethylglycine, aminoalkylbenzyl, aminoalkyl or carboxyalyl ester.
Dependencies are inferred from the claim text.