Compounds for the management of aging-related and diabetic vascular complications, process for their preparation and therapeutic uses thereof

A compound represented by general formula (I), or a pharmaceutically acceptable salt thereof

• wherein
• Y is —C(O)R1;
• R1 is —R4—R5 or —N(R7)N(R7)R9;
• R4 is selected from the group consisting of —N(R7)R6O—, —N(R7)R6N(R7)—, —OR6O—, and —OR6N(R7)—, where R6 is alkyl with C2-C8 carbon atoms;
• R5 is selected from the group consisting of alkyl, aryl containing up to two conjugated or fused ring systems including heteroaryl, —COR7, —SO2R7, —C(S)NHR7, —C(NH)NHR7, —COR10, and —C(O)NHR7 where R7 is selected from the group consisting of H, alkyl and aryl containing up to two conjugated or fused ring systems including heteroaryl, provided R7 may be the same or different for R1 and R3 in the same compound;
• R2 is selected from the group consisting of F, Cl, Br, I, OR7, NO2, alkyl, aryl containing up to two conjugated or fused ring systems including heteroaryl, formyl, acyl, C(O)NR7R10, C(O)OR7, NR7R10, SR7, SO2NH2, SO2alkyl and SO2aryl;
• m is 0, 1 or 2;
• R is —CH2—C(O)—R3;
• R3 is selected from the group consisting of R7, —O-alkyl, —O-aryl, N(R7)(R10), N(R7)N(R7)(R10), and CH(R7)C(O)R8 where R8 is selected from the group consisting of R7, OR7 and NR7R10;
• R9 is selected from the group consisting of hydrogen, alkyl, aryl containing up to two conjugated or fused ring systems including heteroaryl, —C(O)R10, —SO2R10, —C(S)NHR10, —C(NH)NH(R10) and —C(O)NHR10;
• R10 is selected from the group consisting of H, alkyl and aryl containing up to two conjugated or fused ring systems including heteroaryl and in each case may be the same or different from substituent R7, provided R10 may be the same or different for R1 and R3 in the same compound;
• X is selected from group consisting of a halide ion, acetate ion, perchlorate ion, sulfonate ion, oxalate ion, citrate ion, tosylate ion, maleate ion, mesylate ion, carbonate ion, sulfite ion, phosphoric hydrogen ion, phosphonate ion, phosphate ion, BF4− and PF6−;
• with proviso that,
• (i) when two alkyl groups are present on the same carbon or nitrogen, they may be linked together to form a cyclic structure;
• and
• (ii) the nitrogen of heteroaryl ring of R10, when present, may be quaternized with a compound X—CH2—C(O)—R3, where X and R3 have the meaning as given above.