Process for purifying 6-methoxy omeprazole
OwnerLinda B. Whittall, Grayson Walker Stowell +1inventors
InventorsLinda B. Whittall, Grayson Walker Stowell, Robert R. Whittle
Life of this patent
Estimating the term…
Abstract
The present invention provides processes for purifying 6-methoxy omeprazole, products using such processes, pharmaceutical formulations using such products, and methods of using such products for gastric acid inhibition.
Claims15
A method for increasing the solid state percentage of 6-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole, or a pharmaceutically acceptable salt, hydrate, or combination thereof from an amount of 5(6)-methoxy-2-[[(4-mehoxy-3,5-dimethyl-2-pyridinyl)-methyl]sulfinyl]-1H-benzimidazole, or a pharmaceutically acceptable salt, hydrate, or combination thereof comprising:
- (a) rinsing, one or more times, said amount of 5(6)-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole with a solvent selected from the group consisting of a short carbon chain alcohol solvent and tetrahydrofuran;
- (b) drying the product from step (a).
A method for increasing the solid state percentage of 6-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-l H-benzimidazole, or a pharmaceutically acceptable salt, hydrate, or combination thereof from an amount of 5(6)-methoxy-2-[[(4-mehoxy-3,5-dimethyl-2-pyridinyl)-methyl]sulfinyl]-1H-benzimidazole, or a pharmaceutically acceptable salt, hydrate, or combination thereof, wherein said 5(6)-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole has a percentage of 5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole greater than about nine percent comprising:
- (a) rinsing said amount of 5(6)-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole with a solvent selected from the group consisting of a short carbon chain alcohol solvent and tetrahydrofuran;
- and
- (b) drying the product from step (a).
A method for decreasing the amount of 5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1 H-benzimidazole, or a pharmaceutically acceptable salt, hydrate, or combination thereof, from an amount of 5(6)-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1 H-benzimidazole, or a pharmaceutically acceptable salt, hydrate, or combination thereof, wherein said 5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole is reduced to an amount less than about ten percent of the total 5(6)-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole comprising:
- (a) rinsing, one or more times, said amount of 5(6)-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]- 1H-benzimidazole with a solvent selected from the group consisting of a short carbon chain alcohol solvent and tetrahydrofuran;
- and
- (b) drying the product from step (a).
Dependencies are inferred from the claim text.