Il-8 receptor antagonists

A compound of the formula (I):

• wherein
• Rb is independently selected from the group consisting of hydrogen, NR6R7, OH, ORa, C1-5alkyl, aryl, arylC1-4alkyl, aryl C2-4alkenyl, cycloalkyl, cycloalkyl C1-5 alkyl, heteroaryl, heteroarylC1-4alkyl, heteroarylC2-4 alkenyl, heterocyclic, heterocyclic C1-4alkyl, and a heterocyclic C2-4alkenyl moiety, all of which moieties may be optionally substituted one to three times independently by a substituent selected from the group consisting of halogen, nitro, halosubstituted C1-4 alkyl, C1-4 alkyl, amino, mono or di-C1-4 alkyl substituted amine, ORa,C(O)Ra,NRaC(O)ORa, OC(O)NR6R7, hydroxy, NR9C(O)Ra, S(O)m′Ra, C(O)NR6R7, C(O)OH, C(O)ORa, S(O)2NR6R7 and NHS(O)2Ra;
• or the two Rb substituents join to form a 3-10 membered ring, optionally substituted and containing, in addition to carbon, independently, 1 to 3 optionally substituted moieties selected from the group consisting of NRa, O, S, SO, and SO2;
• Ra is selected from the group consisting of alkyl, aryl, arylC1-4alkyl, heteroaryl, heteroaryl C1-4alkyl, heterocyclic, COORa, and a heterocyclic C1-4alkyl moiety, all of which moieties may be optionally substituted;
• m is an integer having a value of 1 to 3;
• m′ is 0, or an integer having a value of 1 or 2;
• n is an integer having a value of 1 to 3;
• q is 0, or an integer having a value of 1 to 10;
• t is 0, or an integer having a value of 1 or 2;
• s is an integer having a value of 1 to 3;
• R1 is independently selected from the group consisting of hydrogen, halogen, nitro, cyano, C1-10 alkyl, halosubstituted C1-10 alkyl, C2-10 alkenyl, C1-10 alkoxy, halosubstituted C1-10alkoxy, azide, S(O)tR4, (CR8R8)q S(O)tR4, hydroxy, hydroxy substituted C1-4alkyl, aryl, aryl C1-4 alkyl, aryl C2-10 alkenyl, aryloxy, aryl C1-4 alkyloxy, heteroaryl, heteroarylalkyl, heteroaryl C2-10 alkenyl, heteroaryl C1-4 alkyloxy, heterocyclic, heterocyclic C1-4alkyl, heterocyclicC1-4alkyloxy, heterocyclicC2-10 alkenyl, (CR8R8)q NR4R5, (CR8R8)qC(O)NR4R5, C2-10 alkenyl C(O)NR4R5, (CR8R8)q C(O)NR4R10, S(O)3R8, (CR8R8)q C(O)R11, C2-10 alkenyl C(O)R11, C2-10 alkenyl C(O)OR11, (CR8R8)q C(O)OR11, (CR8R8)q OC(O)R11, (CR8R8)qNR4C(O)R11, (CR8R8)q C(NR4)NR4R5, (CR8R8)q NR4C(NR5)R11, (CR8R8)q NHS(O)2R13, and (CR8R8)q S(O)2NR4R5;
• or two R1 moieties together may form O—(CH2)sO or a 5 to 6 membered saturated or unsaturated ring, such that the alkyl, aryl, arylalkyl, heteroaryl, or heterocyclic moieties may be optionally substituted;
• R4 and R5 are independently selected form the group consisting of hydrogen, optionally substituted C1-4 alkyl, optionally substituted aryl, optionally substituted aryl C1-4alkyl, optionally substituted heteroaryl, optionally substituted heteroaryl C1-4alkyl, heterocyclic, and heterocyclicC1-4 alkyl, or R4 and R5 together with the nitrogen to which they are attached form a 5 to 7 member ring which may optionally comprise an additional heteroatom selected from O, N and S;
• R6 and R7 are independently selected from the group consisting of hydrogen, a C1-4 alkyl, heteroaryl, aryl, aklyl aryl, and alkyl C1-4 heteroalkyl;
• or R6 and R7 together with the nitrogen to which they are attached form a 5 to 7 member ring which ring may optionally contain an additional heteroatom which is selected from the group consisting of oxygen, nitrogen or sulfur, and which ring may be optionally substituted;
• Y is selected from the group consisting of furan, thiophene, pyrrole, oxazole, imidazole, thiazole, thieno(2,3 b)pyridine, pyrazole, isooxazole, isothiazole, 1,2,3 or 1,2,4 oxadiazole, 1,2,3 or 1,2,4 triazole, 1,2,3 or 1,2,4 thiadiazole, pyridine, pyridine-N-oxide, pyrimidine, pyridazine, pyrazine, 1,3,5, or 1,2,3 or 1,2,4 triazine, 1,2,4,5 tetrazine, indole, benzofuran, indazole, benzimidazole, benzothiazole, quinoline, isoquinoline, cinnoline, phthalazine, quinazoline and quinoxaline all of which moeities can be substituted 1-3 times with R1
• R8 is hydrogen or C1-4 alkyl;
• R9 is hydrogen or a C1-4 alkyl;
• R10 is C1-10 alkyl C(O)2R8;
• R11 is selected from the group consisting of hydrogen, optionally substituted C1-4 alkyl, optionally substituted aryl, optionally substituted aryl C1-4alkyl, optionally substituted heteroaryl, optionally substituted heteroarylC1-4alkyl, optionally substituted heterocyclic, and optionally substituted heterocyclicC1-4alkyl;
• and
• R13 is selected from the group consisting of C1-4 alkyl, aryl, aryl C1-4alkyl, heteroaryl, heteroarylC1-4alkyl, heterocyclic, and heterocyclicC1-4alkyl;
• or a pharmaceutically acceptable salt thereof.