Use of methylnaltrexone and related compounds
AssigneesThe University of Chicago, UR Labs, Inc.
InventorsJoseph F. Foss, Michael F. Roizen, Jonathan Moss, Chun-Su Yuan, William Drell
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Abstract
A method for preventing or treating opioid induced changes in gastrointestinal motility. The method comprises administering methylnaltrexone or another quaternary derivative of noroxymorphone to a patient prior to the administration of an opioid or after the onset of side effects induced by the administration of an opioid, wherein the methylnaltrexone or quaternary derivative is administered orally in an enterically coated form.
Claims38
A method for preventing opioid induced inhibition of gastrointestinal motility comprising orally administering an enterically coated quaternary derivative of noroxymorphone to a patient prior to the administration of an opioid, wherein the patient's plasma level of the quaternary derivative of noroxymorphone does not exceed 50 ng/ml.
A method for treating opioid induced inhibition of gastrointestinal motility comprising orally administering an enterically coated quaternary derivative of noroxymorphone to a patient subsequent to the administration of an opioid, wherein the patient's plasma level of the quaternary derivative of noroxymorphone does not exceed 50 ng/ml.
A method for treating endogenous opioid induced inhibition of gastrointestinal motility comprising orally administering an enterically coated quaternary derivative of noroxymorphone to a patient in an amount effective to treat the inhibition, wherein the inhibition is induced by endogenous opioids.
A method for preventing inhibition of gastrointestinal motility in a patient receiving an opioid for pain resulting from surgery comprising administering a quaternary derivative of noroxymorphone to the patient in an amount effective to prevent the inhibition.
A method for treating inhibition of gastrointestinal motility in a patient receiving an opioid for pain resulting from surgery comprising administering a quaternary derivative of noroxymorphone to the patient in an amount effective to treat the inhibition.
Dependencies are inferred from the claim text.