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US 6,608,067 B1Granted
Inhibitors of serine proteases, particularly HCV NS3 protease
AssigneeVertex Pharmaceuticals Incorporated
InventorsRoger D. Tung, Govinda Rao Bhisetti, Luc J. Farmer
Life of this patent
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Abstract
The present invention relates to compounds, methods and pharmaceutical compositions for inhibiting proteases, particularly serine proteases, and more particularly HCV NS3 proteases. The compounds, and the compositions and methods that utilize them, can be used, either alone or in combination to inhibit viruses, particularly HCV virus.
Claims13
A compound of the formula (I):
- wherein:
- W is:
- wherein:
- m is 0 or 1;
- each R2 is H;
- J is selected from t-butyl, methyl, trifluoromethyl, hydroxy, methoxy, ethoxy, trifluoromethoxy, carboxy, phenyl, benzyl, phenoxy, benzyloxy, fluoro, chloro, bromo, isoxazolyl, pyridinyl, piperidinyl, carboxymethyl, carboxyethyl, dialkylamino, morpholinylmethyl, phenylacetylamino, or acylamino, wherein each J is optionally substituted with 1-3 J1 groups;
- each J1 is independently selected from C1-3 alkoxy, chloro, C1-3 alkyl, or phenyl;
- L is CH2CH3 or CH2CF3;
- each M is independently selected from isopropyl, propyl, methyl, pyridylmethyl, benzyl, naphthylmethyl, phenyl, imidazolylmethyl, thiophenylmethyl, cyclohexylmethyl, phenethyl, benzylthiomethyl, or benzyloxyethyl;
- R18 is —N(R11)—;
- R11 is hydrogen or C1-C3 alkyl;
- one R19 is —O—(C1-C3)-alkyl-aryl and the other two R19 are H;
- or two adjacent R19 are bound together to form phenyl ring and the other R19 is H;
- n is 1;
- the ring to which R18 and R19 are attached is phenyl;
- A2 is a bond or —N(R11)—C(H)(M)—C(O)—;
- V is —N(R11)—;
- K is —C(O)—;
- and
- T is —R12 or -alkyl-R12;
- wherein:
- each R12 is independently aryl or heteroaryl and is optionally substituted with 1 to 3 J groups.
19 more elements
Dependencies are inferred from the claim text.