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US 6,608,059 B1Granted
Fatty acid synthase inhibitors
AssigneeSmithKline Beecham Corporation
InventorsRobert A. Daines, Israil Pendrak
Life of this patent
Estimating the term…
Abstract
This invention relates to the use of compounds as inhibitors of the fatty acid synthase FabH.
Claims4
A compound according to Formula (I):
- wherein,
- R1 is selected from the group consisting of H, CO2R4, COR4, CONR5R6, CH(OH)R4, CR4═NOR4, heteroaryl and substituted heteroaryl;
- R2 is selected from the group consisting of H, COR4, and CH(OH)R4;
- R3 is selected from the group consisting of aryl, substituted aryl, heteroaryl and substituted heteroaryl;
- R4 is H or lower alkyl;
- R5 and R6 are, independently, H, or lower alkyl or, together, form a 5 or 6 membered ring selected from the group consisting of piperidine, piperazine, pyrrolidine, morpholine and hydroxy piperidine;
- and
- n is an integer from 1 to 6;
- or a pharmaceutically acceptable salt thereof or a pharmaceutically acceptable salt complex thereof.
6 more elements
Dependencies are inferred from the claim text.