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US 6,608,055 B2Granted
Crystalline anticholinergic, processes for preparing it and its use for preparing a pharmaceutical composition
AssigneeBoehringer Ingelheim Pharma GmbH & Co. KG
InventorsPeter Sieger, Ulrike Werthmann
Life of this patent
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Abstract
The invention relates to crystalline anhydrous (1α,2β,4β,5α,7β)-7-[(hydroxydi-2-thienylacetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.022,4]nonane-bromide, processes for preparing it and its use for preparing a pharmaceutical composition, particularly for preparing a pharmaceutical composition with an anticholinergic activity.
Claims18
Anhydrous cyrstalline tiotropium bromide.
A process for preparing crystalline, anhydrous tiotropium bromide which comprises
- (a) dissolving tiotropium bromide in water;
- (b) heating the resulting solution;
- (c) crystallizing the hydrate of tiotropium bromide while cooling slowly;
- and
- (d) drying the resulting crystalline tiotropium bromide monohydrate.
2 more elements
Dependencies are inferred from the claim text.