Lyophilizate of lipid complex of water insoluble porphyrins
AssigneePharmacia & Upjohn Company
InventorsMathew Cherian, Shireesh Prakash Apte
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Abstract
The present invention relates to a pharmaceutically acceptable dosage form of water insoluble porphyrins, particularly metal containing porphyrins such as tin porphyrin, which can be complexed with a lipid, reconstituted from a lyophilizate and administrated to a patient in the treatment of cancer and other diseases.
Claims16
A pharmaceutical composition comprising a lyophilizate of a complex of a porphyrin, a phospholipid, and a pharmaceutically acceptable lyophilization excipient, wherein the porphyrin has the structure:
A method for preparing a lyophilizate of a lipid complex of a porphyrin which comprises the steps of preparing a concentrated solution of a porphyrin and a phospholipid in an organic solvent, adding water to the solution to cause formation of a complex of the porphyrin and the phospholipid, removing the organic solvent to provide a dispersion of the lipid complex in water as an aqueous phase, dissolving a pharmaceutically acceptable excipient in the aqueous phase of the dispersion, and lyophilizing the dispersion of the lipid complex to form a lyophilizate, wherein said porphyrin has the structure:
A method of photodynamic therapy comprising the steps of:
- administering an effective amount of a lyophilizate of a complex of a porphyrin, a phospholipid, and a pharmaceutically acceptable lyophilization excipient to a patient;
- and
- exposing said patient to radiation at a wavelength in the absorption spectrum of said porphyrin,
- wherein the porphyrin has the structure:
Dependencies are inferred from the claim text.