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US 6,608,047 B2Granted
Use of low dosage amount of spironolactone for treatment of cardiovascular disease
AssigneePharmacia Corporation
InventorsTodd E. MacLaughlan, Alfonso T. Perez
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Abstract
Use of low dosages of an aldosterone receptor antagonist, spironolactone, is described for treatment of circulatory disorders. This therapy would be particularly useful to treat or retard the development of congestive heart failure, while avoiding or reducing aldosterone-antagonist-induced side effects, such as hyperkalemia.
Claims5
A method to treat a human patient suffering from hypertension, said method comprising administering to said patient an amount of spironolactone sufficient to substantially decrease circulating levels of N-terminal ANF.
Dependencies are inferred from the claim text.