Chemical modification of biomedical materials with genipin
AssigneeChallenge Bioproducts Co., Ltd.
InventorsChing-Kuan Lin, Thomas Chau-Jen Lee, Hsing-Wen Sung
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Abstract
Biocompatible cross-linked materials, suitable for use in implants, wound dressings, and blood substitutes, are described. The materials are prepared by cross-linking biological substances, such as collagen, chitosan, or hemoglobin, with genipin, a naturally occurring cross-linking agent. The cross-linking agent has much lower toxicity than conventionally used reagents, and the cross-linked products have good thermal and mechanical stability as well as biocompatibility.
Claims17
A method of providing a biocompatible implant, comprising (i) procuring a tissue material comprising genipin-crosslinkable collagenous tissue, wherein the tissue material is characterized by suitable tensile strength, and (ii) crosslinking said tissue material with genipin to produce a crosslinked structure, said crosslinked structure having stability to degradative enzymes, low acute toxicity, and durability as the biocompatible implant.
A method of preparing a biocompatible adhesive comprising crosslinking a gelatin with an amount of genipin effective to yield a desired adhesiveness and consistency, wherein said gelatin is derived from hydrolytic treatment of collagen or a collagen-containing tissue.
A composition suitable for use in a blood substitute, comprising hemoglobin crosslinked with genipin.
A method of preparing crosslinked hemoglobin, comprising treating hemoglobin with an amount of genipin effective to crosslink said hemoglobin.
A method of providing a biocompatible wound dressing comprising:
- (i) procuring a tissue material comprising genipin-crosslinkable collagenous tissue;
- (ii) crosslinking said tissue material with genipin to produce a crosslinked structure, said crosslinked structure having stability to degradative enzymes and low acute toxicity as the biocompatible wound dressing;
- and (iii) fabricating said crosslinked structure to a proper shape and size configured for use as the biocompatible wound dressing.
Dependencies are inferred from the claim text.