Immunovectors for the intracellular and intranuclear transport
AssigneesInstitut Pasteur, Universite Pierre et Marie Curie (Paris VI)
InventorsStratis Avrameas, Gerard Buttin, Therese Ternynck, Faridabano Nato, Alexandre Avrameas
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Abstract
A product for coupling a biologically active principle with an immunovector, characterized in that the immunovector is capable of enabling the biologically active principle to be internalized into eukaryotic cells, and in that said immunovector has an affinity for the cell DNA to such an extent that it can transfer the biologically active principle into or to the immediate vicinity of the cell nuclei.
Claims17
A product comprising an antibody which recognizes an epitope contained in a nucleic acid, said antibody is coupled to a biologically active principle, wherein said biologically active principle is a protein, or a nucleic acid;
- and wherein said antibody is produced by a hybridoma selected from the group consisting of I-1605, I-1606, and I-1607.
A method of transferring a biologically active principle of interest into a cell comprising:
- coupling an antibody which recognizes an epitope contained in a nucleic acid with the biologically active principle thereby forming a coupled biologically active principle;
- and
- incubating the coupled biologically active principle with the cell, wherein said coupled principle is transferred through the cell membrane and into the cell and wherein said biologically active principle is a protein, or a nucleic acid.
Dependencies are inferred from the claim text.