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US 6,608,028 B1Granted
Insulin-like growth factor agonist molecules
AssigneeGenentech, Inc.
InventorsYvonne Man-yee Chen, Ross G. Clark, Andrea G. Cochran, Henry B. Lowman, Iain C. A. F. Robinson, Nicholas J. Skelton
Life of this patent
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Abstract
Peptides are provided that inhibit the interaction of an IGF with any one of its binding proteins and not to a human IGF receptor. These IGF agonist peptides are useful to increase serum and tissue levels of active IGFs in a mammal.
Claims23
A peptide comprising the following sequence:
- Xaa(1-4)CysXaa(6)Xaa(7)GlyXaa(9)Xaa(10)Xaa(11)Xaa(12)Xaa(13)CysXaa(15)Xaa(16)Xaa(17)Xaa(18)(SEQ ID NO:1), wherein Xaa(1-4) is absent or is between 1 and 4 amino acids of any kind, Xaa(6), Xaa(7), Xaa(9), Xaa(11), Xaa(15), and Xaa(16) are independently any amino acid, Xaa(10) and Xaa(13) are independently Leu or Nle, and Xaa(12), Xaa(17), and Xaa(18) are independently Nal(1), His, Phe, Trp, Tyr, Pro, Gln, or Met, wherein the first and second Cys residues of SEQ ID NO:1 are linked via a disulfide bond, and wherein the peptide inhibits the binding of IGFBP-1 to IGF-1.
A peptide comprising one of the following sequences:
- CysArgAlaGlyAlaLeuGlnTrpLeuCysGluLysTyrPhe (SEQ ID NO:4);
- CysArgAlaGlyArgLeuGlnTrpLeuCysGluLysTyrPhe (SEQ ID NO:5);
- CysArgAlaGlyAsnLeuGlnTrpLeuCysGluLysLyrPhe (SEQ ID NO:6);
- CysArgAlaGlyProNleGlnTrpLeuCysGuLysTyrPhe (SEQ ID NO:7);
- CysArgAlaGlyProLeuGlnTrpNleCysGluLysTyrPhe (SEQ ID NO:8);
- CysArgAlaGlyProLeuGlnArgLeuCysGluLysTyrPhe (SEQ ID NO:9);
- CysArgAlaGlyProLeuGlnNal(1)LeuCysGluLysTyrPhe (SEQ ID NO:10);
- or
- CysArgAlaGlyProLeuGlnHisLeuCysGluLysTyrPhe (SEQ ID NO:11).
6 more elements
Dependencies are inferred from the claim text.