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US 6,607,916 B2Granted
Antisense inhibition of Casein kinase 2-alpha expression
AssigneeIsis Pharmaceuticals, Inc.
InventorsSusan M. Freier, Jacqualine Wyatt
Life of this patent
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Abstract
Antisense compounds, compositions and methods are provided for modulating the expression of Casein kinase 2-alpha. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Casein kinase 2-alpha. Methods of using these compounds for modulation of Casein kinase 2-alpha expression and for treatment of diseases associated with expression of Casein kinase 2-alpha are provided.
Claims14
A compound up to 50 nucleobases in length comprising at least an 8-nucleobase portion of SEQ ID NO:
- 20, 21, 22, 23, 24, 25, 26, 27, 28, 30, 32, 34, 35, 37, 38, 39, 40, 41, 42, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 90, 91, 92, 93, 95 or 96 which inhibits the expression of human Casein kinase 2-alpha.
A compound consisting of SEQ ID NO:
- 19, 43, 44 or 45.
Dependencies are inferred from the claim text.