Compositions and methods relating to control DNA construct

An isolated control DNA construct comprising a vector portion for expression in a cell and a target nucleic acid comprising two or more nucleic acid fragments wherein each fragment specifies a component associated with at least one of a disease state, an environmental condition, or a biological organism, wherein said component is different from a component specified by any other fragment present elsewhere in said construct, and wherein the 5′-most fragment is linked to said vector portion via a restriction site not present elsewhere in said construct, and wherein the 3′-most fragment is linked to said vector portion via a restriction site not present elsewhere in said construct, and further wherein each said fragment is flanked by a restriction site not present elsewhere in said construct, wherein said fragments comprise a nucleic acid selected from the group consisting of a Giardia lamblia nucleic acid, a Cryptosporidium parvum nucleic acid, a human immunodeficiency virus nucleic acid, a hepatitis C virus nucleic acid, a factor V nucleic acid, a Chlamydia trachomatis nucleic acid, a Mycobacterium tuberculosis nucleic acid, a nucleic acid associated with hereditary hemochromatosis, a parvovirus B19 nucleic acid, a lipoprotein lipase gene, a methyltetrahydrofolate reductase gene, a beta cystathionase synthetase nucleic acid, a Factor II nucleic acid, a Factor VII nucleic acid, a Factor VIII nucleic acid, Factor IX nucleic acid, a prothrombin nucleic acid, and a nucleic acid comprising a translocation associated with hematologic disease, wherein said nucleic acid comprising a translocation associated with hematologic disease is a BCR/abl nucleic acid.