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US 6,607,897 B2Granted
Recombinant proCVF
AssigneeGeorgetown University
InventorsCarl-Wilhelm Vogel, Reinhard Bredehorst, David Fritzinger, Michael Kock
Life of this patent
Estimating the term…
Abstract
Recombinant proCVF exhibits substantially the same activity as CVF and is useful for lowering complement activity.
Claims20
An isolated segment of DNA, which encodes a polypeptide comprising an amino acid sequence selected from the group consisting of:
- (a) amino acids 1-1620 of SEQ ID NO:2 with 1 to 8 histidine residues added to the carboxy terminus;
- (b) amino acids 23-1620 of SEQ ID NO:2 with 1 to 8 histidine residues added to the carboxy terminus;
- (c) amino acids 23 to 1620 of SEQ ID NO:2 with 1 to 8 histidine residues added to the carboxy terminus and a methionine residue added to the amino terminus;
- and
- (d) amino acids 23 to 1620 of SEQ ID NO:2 with 1 to 8 histidine residues added to the carboxy terminus and a signal peptide at the amino terminus, wherein the signal peptide comprises SEQ ID NO:36.
2 more elements
Dependencies are inferred from the claim text.