Controlled release delivery device for pharmaceutical agents incorporating microbial polysaccharide gum
AssigneeIntellipharamaceutics Corp.
InventorsIsa Odidi, Amina Odidi
Life of this patent
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Abstract
The present invention provides a controlled release device for sustained or pulsatile delivery of pharmaceutically active substances for a predetermined period of time. This invention further provides such device in which sustained or pulsatile delivery is obtained by the unique blend and intimate mixture of pharmaceutically active substances with a microbial polysaccharide and uncrosslinked linear polymer and optionally a crosslinked polymer and/or lipophillic polymer and/or lipophillic polymer and/or saturated polyglycolyzed glyceride. The invention also provides for the manufacture of such devices and pharmaceutical compositions containing the same.
Claims20
A controlled release pharmaceutical device which provides sustained or pulsatile delivery of pharmaceutically active substances for a predetermined period of time, the device comprising;
- about 25 to 60% by weight microbial polysaccharide;
- and
- about 15 to 60% by weight cellulose ether.
A pharmaceutical composition comprising:
- over 25 to 60% by weight microbial polysaccharide;
- about 15 to 60% by weight cellulose ether;
- and
- about 1 to 80% by weight pharmaceutical active.
A pharmaceutical composition comprising;
- about 25 to 60% by weight xanthan gum;
- about 15 to 60% by weight cellulose ether;
- about 1 to 80% by weight pharmaceutical active;
- at least one of the agents selected from the group consisting of;
- about 1 to 50% by weight crosslinked acrylic acid polymer;
- about 1 to 50% by weight lipophillic polymer selected from the group consisting of glyceryl behenate, glyceryl palmitostearate and glyceryl stearate;
- about 1 to 50% saturated polyglycolyzed glyceride
- about 0.5 to 10% by weight lubricant selected from the group consisting of at least one of magnesium stearate and talc;
- and
- about 1 to 65% by weight granulating or tableting aids selected from the group consisting of silicone dioxide, microcrystalline cellulose, calcium phosphate, sodium laurel sulphate, calcium sulphate and silicified microcrystalline cellulose and mixtures thereof.
A controlled release pharmaceutical composition comprising about 55% by weight naproxyn sodium, about 10% by weight microcrystalline cellulose, about 10% by weight xanthan gum, about 14% by weight hydroxypropylmethyl cellulose, about 9% by weight saturated polyglycolyzed glyceride, about 1% by weight talc and about 1% by weight magnesium stearate.
Dependencies are inferred from the claim text.