Suppository composition which is a spray-dried suspension of an acid-labile proton pump inhibitor in a solvent solution of a sterol and polymer
AssigneeAltana Pharma AG
InventorsRudolf Linder, Rango Dietrich
Life of this patent
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Abstract
Acid-labile active compounds are prepared in suppository form, particularly for rectal administration.
Claims32
A method of treating a condition treatable with a pyridin-2-ylmethylsulfinyl-1H-benzimidazole, which comprises administering to a subject prone to or afflicted with the condition a pharmaceutically acceptable suppository composition comprising an effective amount of an acid-labile proton pump inhibitor, a sterol and a polymer, and which is a spray-dried suspension of the acid-labile proton pump inhibitor in a suitable-solvent solution of the sterol and the polymer;
- wherein the condition is a disease of the stomach.
A method of treating a disease of the stomach treatable with a pyridin-2-ylmethylsulfinyl-1H-benzimidazole, which comprises administering to a subject afflicted with the condition a pharmaceutically acceptable suppository composition comprising an effective amount of an acid-labile proton pump inhibitor and
- a) at least one fatty alcohol, the composition being a spray congealed suspension of the acid-labile compound proton pump inhibitor in the fatty alcohol;
- b) a mixture of at least one fatty alcohol and at least one polymer, the composition being a spray congealed suspension of the acid-labile proton pump inhibitor in a solution of the polymer in the fatty alcohol;
- c) a mixture of at least one fatty alcohol and at least one sterol, the composition being a spray congealed suspension of the acid-labile proton pump inhibitor in a solution of die sterol in the fatty alcohol;
- or
- d) a mixture of at least one fatty alcohol, at least one polymer and at least one sterol, the composition being a spray congealed suspension of the acid-labile proton pump inhibitor in a solution of the polymer and sterol in the fatty alcohol.
A method of treating a disease of the stomach treatable with a pyridin-2-ylmethylsulfinyl-1H-benzimidazole, which comprises administering to a subject afflicted with the condition a pharmaceutically acceptable suppository for an acid-labile compound wherein the acid-labile compound is an acid-labile proton pump inhibitor, a salt of an acid-labile proton pump inhibitor with a base or a hydrate of a salt of an acid-labile proton pump inhibitor with a base comprising at least one pharmaceutical auxiliary and a plurality of individual active compound units, wherein the acid-labile active compound in each individual active compound unit is surrounded by a mixture of at least one sterol and at least one polymer, by at least one fatty alcohol or by a mixture of at least one fatty alcohol and at least one polymer and/or at least one sterol.
Dependencies are inferred from the claim text.