Conjugates of sodium channel blockers and methods of using the same
AssigneeThe University of North Carolina at Chapel Hill
InventorRichard C. Boucher, Jr.
Life of this patent
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Abstract
Compounds of the general formula P1-L-P2; wherein “P1” is a pyrazinoylguanidine sodium channel blocker, “L” is a linking group, and “P2” is either (i) a pyrazinoylguanidine sodium channel blocker or (ii) a P2Y2 receptor agonist, are disclosed. Pharmaceutical formulations containing the same and methods of use thereof to hydrate mucosal surfaces such as airway mucosal surfaces are also disclosed.
Claims8
A method of treating a mucosal surface in a subject in need thereof, comprising administering to said subject a compound of the formula P1-L-P2, wherein:
- P1 is a pyrazinoylguanidine sodium channel blocker;
- L is a linking group;
- and
- P2 is selected from the group consisting of pyrazinoylguanidine sodium channel blockers and P2Y2 receptor agonists;
- or a pharmaceutically acceptable salt thereof in an amount effective to treat said mucosal surface.
A method of treating a mucosal surface in a subject in need thereof, comprising administering to said subject, in an amount effective to treat a mucosal surface, a compound comprising a covalent conjugate of a pyrazinoylguanidine sodium channel blocker and a non-absorbable carrier moiety.
Dependencies are inferred from the claim text.